Royal Air Force Typhoon jets have operated alongside French warplanes in a combined operation targeting an underground arms cache in Syria operated by the IS group, as stated by the UK Ministry of Defence.
The site, pinpointed through intelligence, was believed to be containing munitions and bombs, the release indicated, and was positioned in mountains just above the ancient city of Palmyra in Syria's central region.
"The RAF jets employed laser-guided Paveway IV weapons to strike a several approach shafts leading to the depot... initial indications suggest the target was engaged successfully," officials stated.
There was no evidence of any civilian impact in the operation on Saturday evening and all the aircraft returned safely, the defence officials confirmed.
The British jets were supported by a Voyager refuelling tanker.
IS - referred to as the so-called Islamic State - imposed jihadist rule over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This action demonstrates our UK leadership, and determination to stand shoulder to shoulder with allied nations, to eliminate any re-emergence of Daesh and their dangerous and violent ideologies in the area," Britain's Defence Chief John Healey said.
RAF aircraft have carried out patrols over Syria to "prevent any attempted comeback" of Islamic State following its military defeat at the battle of Baghuz in 2019, the MoD reported.
"I want to thank all the members of the UK armed forces involved in this mission for their professionalism and their bravery," he said. "Including them were a great many British troops deployed over Christmas and New Year. This mission, to take out dangerous terrorists who endanger our security, highlights how our armed forces are ready to step up, all year round, protecting the UK domestically and powerful internationally."
In December, the United States armed forces carried out what it called a "large-scale strike" against IS targets in Syria, following an ambush killed two US servicemembers and a local interpreter in the Palmyra area.
The UN reports IS still boasts an estimated 5,000 to 7,000 combatants in Iraq and Syria.